The invention relates to a drive circuit applying in a piezoelectric actuating component composed of a drive period generation unit and a switch circuit unit. The drive period generation unit also comprises a drive indexing signal and a programmed microcontroller, wherein the programmed microcontroller generates a programmed drive period signal corresponding to the drive indexing signal after receiving the drive indexing signal and responding to the drive indexing signal. The switch circuit unit generates an alternate drive voltage corresponding to the drive period signal after connecting to the drive period generation unit and the piezoelectric actuating component as well as receiving the drive period signal. The waveform of the half wave leading edge of the alternate drive voltage has agravity curve shape, the waveform of the half wave trailing edge of the alternate drive voltage is close to a vertical shape and the alternate drive voltage is connected to the piezoelectric actuating component.