The present invention relates to an encryption method based on biometric information. The encryption method provides a dual-factor encryption method based on the biometric information and the secret key, and a single-factor encryption method based on the biometric information. And the encryption method can be used in the fields of network and information security, bio-certification, biometric encryption, and so on. The dual-factor encryption and decryption of the information by the user both require the biometric information and the secure secret key or password which is automatically selected; if either of the biometric information and the secure secret key is not correct, the correct plaintext information can not be decrypted. The single-factor encryption and decryption of the information by the user only requires the biometric information. The encryption method can prevent the non-intended message recipient from decrypting the information; the attacker who obtains the decryption key of the other people can not complete the correct decryption process; the decryption process and the physical identity verification are completed simultaneously; the legitimacy of the identity of the decrypting person is verified; and the system has higher security.