The invention provides a chemosynthesis method of pyroglutamic acid alcohol and intermediates thereof, i.e., pyroglutamic acid and pyroglutamic acid ester, wherein, glutamic acid is used as raw material which is dehydrated and cyclized in a heating environment to generate pyroglutamic acid which is then reacted with absolute alcohol under the effect of catalyst to generate pyroglutamic acid ester; finally, pyroglutamic acid ester is dissolved in organic solvent to be reduced by reducing agent to generate pyroglutamic acid alcohol. The chemosynthesizing method has the advantages that the raw material is easy to get, the process route is short, catalyst and acid consumption are little, the operation environment is good, the yield coefficient is high, the cost is low, the purity is high and the method is easy for industrialization.