The invention provides an anti-tumor compound and a method for preparing the same. The method for preparing the anti-tumor compound (3'-{4-[3-(3, 5-di-t-butyl-4-methoxyphenyl)-3-keto-1-propenyl] benzoyl} floxuridine (BOBA-3'- floxuridine ester)) adopts a three-step method of selective protection, esterification and deprotection for synthesis. Compared with floxuridine, BOBA-3'- floxuridine ester has the advantages of prolonging half decay time of the floxuridine, improving fat soluble property of the floxuridine, reducing administration frequency and administration dosage as well as probability and degree of causing adverse reactions; and under the action of in vivo esterase, the BOBA-3'- floxuridine ester can be hydrolyzed into BOBA and the floxuridine, so that the double functional anti-tumor drug which can not only resist metabolism but also induce tumor cells to break up.