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发明公开
CN101514197A 苯并咪唑类质子泵抑制剂的制备新方法 无效 - 撤回 转让

苯并咪唑类质子泵抑制剂的制备新方法
摘要：
本发明提供了一种通式II所示苯并咪唑类质子泵抑制剂制备的新方法。在通式III如[(R’1R’2R’3R’4N)p]+[AmBnOr]－多金属氧酸盐催化剂存在下，用30％过氧化氢作为氧化剂，使通式I所示的硫醚发生选择性氧化。(见图)通式I和II中R1、R2和R3＝H，C1－C5的烷基、C1－C5的烷氧基，C1－C5卤代烷基、C1－C5的醚烷基、或其任意组合，R4＝H、C1－C5的烷基、C1－C5的烷氧基、C1－C5的卤代烷基、或吡咯－2－基，通式III中R’1、R’2、R’3、R’4＝H，C1－C5的烷基，或其任意组合，A为金属Mo，W；B为P，H；x为1－10的整数；n，m，p，r为0－50，或其任意组合。
摘要（英）：

The invention provides a novel method for preparing benzimidazole proton pump inhibitors shown in a general formula II. In the presence of [(R'1R'2R'3R'4N)p][AmBnOr] polyoxometallate catalyst shown in a general formula III, 30 percent peroxide is used as an oxidant to ensure that thioether shown in a general formula I is subjected to selective oxidation. (See chart) in the general formula I and the general formulas II, R1, R2 and R3 are equal to H, C1-C5 alkyl, C1-C5 alkoxyl, C1-C5 haloalkyl, C1-C5 ether alkyl, or any combination thereof, and R4 is equal to the H, the C1-C5 alkyl, the C1-C5 alkoxyl, the C1-C5 haloalkyl, or pyrrol-2-yl; and in the general formula III, R'1, R'2, R'3, and R'4 are equal to the H, the C1-C5 alkyl, or any combination of the H and the C1-C5 alkyl, A is metal Mo and W, B is P and the H, x is an integer between 1 and 10, and n, m, p and r are between 0 and 50 or any combination thereof.

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