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发明公开
CN101555229A 99TcmO核标记硝基咪唑类黄原酸盐配合物及制备方法和应用 失效 - 权利终止

99TcmO核标记硝基咪唑类黄原酸盐配合物及制备方法和应用
摘要：
本发明公开了一种99TcmO核标记硝基咪唑类黄原酸盐配合物，通式为99TcmO(NMXT)2，式中NMXT代表一类含有硝基咪唑类黄原酸盐化合物。该配合物以[99Tcm(V)O]3+为中心核，具有一个不规则的正方角锥型的几何构型，其中Tc＝O键中的O原子位于顶点位置，两个黄原酸盐配体分子提供的四个硫原子位于底面的四个点。通过配体NMXT的合成及99TcmO(NMXT)2配合物制备的工艺步骤，得到99TcmO(NMXT)2配合物。本发明放射化学纯度高、稳定性好、在肿瘤中有较高的摄取值和良好通过的滞留，肿瘤/肌肉比值较高，广泛应用于人体和动物器官的肿瘤显像，是一种方便推广应用的新型肿瘤乏氧显像剂。
摘要（英）：

The invention discloses a nitro imidazole xanthogenate complex marked by TcO with the formula of TcO (NMXT)2; in the formula, NMXT represents a compound containing nitro imidazole xanthogenate. The complex adopts Tc(V)O as a central nucleus and has a geometric configuration with the shape of an irregular square pyramid, wherein O atom in Tc=O bond is positioned at the top point and four sulphur atoms provided by two xanthogenate ligand molecules are positioned at the four points of the bottom surface. By the technical steps of synthesis of ligand NMXT and preparation of TcO (NMXT)2 complex, the TcO (NMXT)2 complex is obtained. The nitro imidazole xanthogenate complex has high radiochemical purity and good stability, has higher uptake value and good detention through in tumor and higher ratio of tumor/muscle, is widely applied to tumor imaging of human body and animal organs and is a novel tumor hypoxia imaging agent which is conveniently promoted and applied.

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