The invention relates to a radio navigation system with a frequency spreading and hopping system, solving the defects of poor capacity of resisting disturbance, easy crack and complex system structure of the existing radio navigation systems. The radio navigation system includes N sending stations and navigation receivers distributed on different positions, wherein N is high than or equal to 3; and a navigation message is processed by the operations of direct spreading modulation and frequency hopping modulation in a frequency spreading and hopping modulation module and then passes through a high pass filter and a power amplifier to be emitted outside by an antennae. At a receiving terminal, the signal received by the antennae passes through a low-noise amplifier and an RF front-end and then enters a frequency spreading and hopping synchronization module. The operations of frequency spreading and hopping are synchronous, and the step of synchronous frequency hopping is carried out firstly, and then the step of synchronous direct spreading is carried out. By utilizing the pseudodistance observed quantity presented by an observed quantity extraction module and the navigation message presented by a navigation message extraction module, a navigation resolving module resolves the positions of the receivers. The frequency spreading and hopping system greatly enhances the capacity of resisting disturbance and crack and reduces the complexity of the radio navigation system system.