The invention discloses an aryl alkanol piperidine derivative and an application thereof as an antidepressive medicine. The aryl alkanol piperidine derivative has triple inhibiting effects on the reuptake of 5-HT, NA and DA, and the antidepressive effect of the aryl alkanol piperidine derivative possibly has wider adaptability and less nervous toxic and side reaction than those of the current clinically used antidepressant with a single-action target point, such as desipramine and fluoxetine and antidepressant with a double-action target point, such as venlafaxine and duloxetine. The derivative can be applied to a patient needing the treatment in a composition way through oral administration, injection, and the like and is a compound or free alkali or salt thereof with the following structural formula.