The invention provides a traditional Chinese medicine pro-liposome injection for treating liver cancer and a preparation process thereof, belonging to the technical field of traditional Chinese medicine preparation. A prescription of the injection comprises 16 to 25 portions of the bunge pricklyash seed olein and 4 to 6 portions of the zedoary turmeric oil by weight. The preparation method comprises the following steps: the bunge pricklyash seed olein medicine materials and the zedoary turmeric oil are prepared to a pro-liposome taking sorbitol as a carrier after being mixed according to a certain ratio and a pro-liposome method. The pro-liposome is shaken by adding water used for injection before being used, and a liposome suspension is formed by hydration to be fed through intravenus drip. A product is a novel pure Chinese drug compound preparation, strengthens the targeting of the drug, enhances the bioavailability, increases the stability of the drug, conceals unpleasant odors, is beneficial to preservation and transportation, has rich raw material sources, low cost and simple preparation technology, and is easy to expand production.