The invention relates to an insoluble medicine solid dispersoid comprising an insoluble medicine and a water-soluble polymer, wherein the mass ratio of the insoluble medicine to the water-soluble polymer is 1-80 : 20-99. A preparation method of the insoluble medicine solid dispersoid comprises the following steps: the insoluble medicine and the water-soluble polymer are together dissolved into water according to the mass ratio of 1-80: 20-99 so as to obtain a suspending solution, and then the temperature of the suspending solution is increased to 70-90 DEG C to form an unsaturated consolute solution; the consolute solution is fast cooled into a solid by liquid nitrogen while the consolute solution is hot and then transferred into a vacuum freezing drier with the vacuum degree of 500 Pa and the temperature of -46 DEG C, and the solid consolute solution is dried for 20-24 hours so as to obtain the insoluble medicine solid dispersoid. The insoluble medicine solid dispersoid utilizes the characteristic of the insoluble medicine, i.e. the dissolubility of the insoluble medicine has temperature dependence in water, to enhance the dissolubility of the medicine and the soluble speed of the medicine and improve the dissolving out property of the medicine by increasing the temperature. The preparation method has easy operation and low cost and is environmentally-friendly, thereby being suitable for industrialized production.