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发明公开
CN101629149A 一种迟钝爱德华氏菌野生毒株的无标记基因缺失减毒突变株、相关制剂及应用 有权

一种迟钝爱德华氏菌野生毒株的无标记基因缺失减毒突变株、相关制剂及应用
摘要：
本发明涉及一种迟钝爱德华氏菌野生毒株的无标记基因缺失减毒突变株，它是迟钝爱德华氏菌毒株的减毒活疫苗，其中缺失了迟钝爱德华氏菌毒株的分支酸合成酶基因aroC，迟钝爱德华氏菌毒株是迟钝爱德华氏菌毒株EIB202，减毒活疫苗还缺失了迟钝爱德华氏菌毒株的内源性质粒，还提供了上述迟钝爱德华氏菌野生毒株的无标记基因缺失减毒突变株的制剂，及相关的在防治养殖鱼类的迟钝爱德华氏菌病中应用，本发明的迟钝爱德华氏菌野生毒株的无标记基因缺失减毒突变株或相关制剂消除了传统减毒活疫苗普遍存在的潜在环境和产品安全风险，是针对养殖鱼类的爱德华氏菌病的一种安全、有效、经济的疫苗。
摘要（英）：

The invention relates to a marker-free gene-deletion attenuated mutant strain derived from an Edwardsiella tarda wild strain, constituting an attenuated live vaccine of the Edwardsiella tarda strain, wherein, chorismate synthase genes aroC of the Edwardsiella tarda strain are deleted; the Edwardsiella tarda strain is particularly an Edwardsiella tarda strain EIB202; and endogenous plasmids of the Edwardsiella tarda strain are further deleted. The invention further provides a preparation for the marker-free gene-deletion attenuated mutant strain derived from the Edwardsiella tarda wild strain, and the related application in preventing mariculture Edwardsiellosis. The marker-free gene-deletion attenuated mutant strain derived from the Edwardsiella tarda wild strain or the related preparation eliminates the potential security risk to the environment and products in most conventional attenuated live vaccines and constitutes a safe, effective and economic vaccine orienting to the mariculture Edwardsiellosis.

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