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发明公开
CN101637442A 一种雷诺嗪口服缓释制剂及其制备方法 无效 - 撤回

一种雷诺嗪口服缓释制剂及其制备方法
摘要：
本发明提供了一种雷诺嗪口服缓释制剂，包括雷诺嗪、缓释骨架材料、填充剂、粘合剂及润滑剂，其特征在于雷诺嗪在缓释制剂中的重量为35％-85％。根据大量的试验优选出处方组成，将羟丙基甲基纤维素邻苯二甲酸酯和甲基纤维素作为本发明缓释制剂的缓释骨架材料，并且优选出其重量比为2∶1-1.5；将微晶纤维素作为添充剂，聚乙烯毗咯烷酮K29/30乙醇溶液作为粘合剂，选硬脂酸镁作为润滑剂。
摘要（英）：

The invention provides a Ranolazine oral sustained-release preparation and a preparation method. The Ranolazine oral sustained-release preparation comprises Ranolazine, a sustained-release skeleton material, a filling agent, an adhesive and a lubricating agent, and is characterized in that the weight of the Ranolazine is between 35 and 85 percent in the sustained-release preparation; a prescription composition is preferably selected according to a large number of experiments; hydroxypropyl methyl cellulose phthalate and methyl cellulose are served as the sustained-release skeleton material ofthe sustained-release preparation in the preferable weight ratio of 2:1-1.5; and microcrystalline cellulose is served as the filling agent; the 29/39 ethanol solution of polyvinyl pyrrolidone K is served as the adhesive, and magnesium stearate is served as the lubricating agent.

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