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发明公开
CN101648916A 制备4-取代-2-哌嗪羧酸的方法 无效 - 撤回

制备4-取代-2-哌嗪羧酸的方法
摘要：
本发明涉及一种4-取代-2-哌嗪羧酸的制备新方法，本发明利用某些过渡金属M 2+ (M＝Cu、Fe、Co、Ni等)离子可与2-哌嗪羧酸的1位氨基和2位羧基(α-氨基酸)络合的特性而同时将它们保护起来；再与R-X反应，R基则选择性地与4位氮原子反应；金属络合物去络合后得到4-取代-2-哌嗪羧酸。此方法具有选择性高(无1位氮取代产物)、操作简单、经济、高效等优点。
摘要（英）：

The invention relates to a novel method for preparing 4-substituted-2-piperazine carboxylic acid. The method comprises: utilizing the characteristic that certain transition metal M<2+> (M is Cu, Fe, Co or Ni and the like) ions can be complex with 1-site amino and 2-site carboxyl (alpha-amino acid) of 2-piperazine carboxylic acid; protecting the transition metal M<2+> at the same time; allowing theobtained product to react with R-X and allowing an R base I to selectively react with 4-site nitrogen atoms; and de-complexing metal complexes to obtain the 4-substituted-2-piperazine carboxylic acid. The method has the advantages of high selectivity (no 1-site nitrogen substitution products), simple operation economical efficiency, high efficiency and the like.

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