The invention relates to an inorganic-organic compound hole sealing coating comprising two parts of a hole sealing layer and an anti-fouling layer, wherein the hole sealing layer is formed by an inorganic hole sealing agent through a dipping-pulling method and a thermal processing method on a test sample after surface processing, the anti-fouling layer is formed by an organic anti-fouling agent through the dipping-pulling method and the thermal processing method on the hole sealing layer, and the inorganic hole sealing agent is an SiO2-Al2O3 colloidal sol hole sealing agent; the organic anti-fouling agent is polytetrafluoroethylene diluent which is prepared by taking polytetrafluoroethylene dispersing liquid, distilled water and a non-ionic type surfactant as raw materials. The preparationmethod of the inorganic-organic compound hole sealing coating provided by the invention comprises two parts of preparing the inorganic hole sealing layer and preparing the organic anti-fouling layer.The inorganic hole sealing layer provided by the invention can obviously lower the porosity of the coating and obviously enhance the erosion resistance performance and the high-temperature resistanceperformance of the coating; the organic anti-fouling layer can effectively lower the surface energy of the coating, enables stains not to be easy to attach to the surface of the coating and has favorable anti-fouling function.