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发明公开
CN101665529A 微波促进固相合成苦瓜MC-JJ22多肽类似物及其应用 无效 - 撤回

微波促进固相合成苦瓜MC-JJ22多肽类似物及其应用
摘要：
本发明涉及新型高效降血糖苦瓜MC-JJ22多肽类似物及其微波促进固相合成方法。通过对天然苦瓜多肽的2，4，5，8或9位点进行改造得到具有更长药理作用时间的MC-JJ22多肽类似物；其化学合成是通过微波促进固相合成方法而得以高效快速实现，粗品经制备级高效液相纯化，最后冻干得到MC-JJ22多肽类似物。
摘要（英）：

The invention relates to a new balsam pear MC-JJ22 polypeptide analogue for efficiently reducing blood glucose and a method for promoting solid phase synthesis of the balsam pear MC-JJ22 polypeptide analogue by microwaves. The MC-JJ22 polypeptide analogue which has longer pharmacological action time is obtained by improving 2,4,5,8 or 9 sites of the natural balsam pear polypeptide, and the chemical synthesis of the balsam pear MC-JJ22 polypeptide analogue is realized efficiently and quickly by the method for promoting solid phase synthesis by microwaves. A crude product is processed by the preparative scale efficient liquid phase purification, and finally, the MC-JJ22 polypeptide analogue is obtained by freeze drying.

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