The invention discloses an integrated treatment process of enhanced flocculation and bio-contact oxidation for high-salt oil-containing wastewater, which uses a two-step serial biochemical reactor combining a push flow bio-contact oxidation reactor and a completely mixed bio-contact oxidation reactor. The treatment process comprises a combined process preparation stage and a treatment stage, wherein the preparation stage comprises the steps of selecting fillers, culturing sludge and hanged membrane, and preparing flocculant; the treatment stage comprises enhanced flocculation treatment and bio-contact oxidation treatment. Cured flocculant adopted by the invention has better flocculation effect and adsorption-bridge capacity for suspended substances and emulsified oil and stronger demulsifying capacity for emulsified oil water, and is applied to treatment of emulsified oil containing wastewater; under change of inflow water quality, flow and saltness, the invention has strong impact resistance on load capacities and stable yielding water quality. The COD of the yielding water is below 40mg/L, and the removing rate reaches 90%. The invention is an efficient way for treating high-salt oil containing wastewater and has vast potential for future development.