The invention relates to a sound insulation band gap material with a two-dimensional serial structure, belonging to the field of acoustics and relating to the fields of condensed matter physics, mechanics, machinery, materials science, and the like. The structure is formed by respectively arraying and serially connecting parallel pipes (solid pipes, hollow metallic pipes or non-metallic pipes) inair according to tetragonal lattices, triangular lattices and honeycomb lattices. The sound insulation band gap material with a two-dimensional serial structure is characterized in that the tetragonal lattices in a gamma-X direction at least include three layers, and the triangular lattices and the honeycomb lattices in a gamma-M direction at least include four layers; the arraying sequences of the three lattices have no relations, and the gamma-X direction of the tetragonal lattices and the gamma-M direction of the triangular lattices and the honeycomb lattices are parallel to the same straight line; and sound waves are transmitted along the gamma-X direction and the gamma-M direction in the serial structure. The sound insulation band gap material with a two-dimensional serial structure can better suppress environmental noise within a frequency range of 1-3kHz which is the most sensitive to the human ears, thereby being used for sound barrier and having wide engineering application potential in reducing the noise of highways, railways, urban traffics and rooms.