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发明公开
CN101812012A 一种制备邻苯二甲酰苏氨酸的方法 无效 - 撤回

一种制备邻苯二甲酰苏氨酸的方法
摘要：
本发明涉及一种制备邻苯二甲酰苏氨酸的方法，其包括以下步骤：第一步，向反应器中加入a毫升非有机碱溶剂、b克邻苯二甲酸酐和c克苏氨酸，将反应器加热至70-150°C保温4-8h；第二步，将第一步反应所得溶液趁热过滤，滤液加入到d毫升蒸馏水中，冷却至3~8°C，用强酸调节pH=2~3，冷却至3~8°C，过滤所得固体即为邻苯二甲酰苏氨酸；a:b=(1.20~2.81):1，b:c=(1.24~1.50):1，d≥4a，所述非有机碱溶剂为N,N-二甲基甲酰胺、二甲基亚砜或1,4-二氧六环中一种。该方法加热温度在70-150°C之间，反应在溶液中进行，反应温和且无爆沸现象，产率达80%以上。
摘要（英）：

The invention relates to a method for preparing o-phthaloyl threonine, which comprises the following steps: firstly, adding a milliliters of inorganic alkaline solvent, b grams of phthalic anhydride and c grams of threonine into a reactor, heating the reactor to 70 to 150 DEG C, and keeping temperature for 4 to 8 hours; and secondly, filtering hot solution obtained by the reaction in the first step, adding the filtrate into d milliliters of distilled water, cooling the solution to 3 to 8 DEG C, adjusting the pH value of the solution to 2 to 3 by using strong acid, and filtering obtained solid to obtain the o-phthaloyl threonine. The ratio of the a to the b is (1.20 to 2.81):1, the ratio of the b to the c is (1.24-1.50):1, and d is more than or equal to 4a; and the inorganic alkaline solvent is N,N-dimethylformamide, dimethyl sulfoxide or 1,4-dioxane. The method has the advantages that: the heating temperature is between 70 and 150 DEG C; the reaction is performed in solution; the reaction is mild without bumping; and the yield is over 80 percent.

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