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发明授权
CN101812452B RALA基因的小干扰RNA在制备抗白血病药物中的应用 有权

RALA基因的小干扰RNA在制备抗白血病药物中的应用
摘要：
本发明公开了一种RALA基因的小干扰RNA及其在制备抗白血病药物中的应用。所述小干扰RNA的序列如下：正义链为：5′-CGUGGAAACAUCUGCUAAATT-3′；反义链为：5′-UUUAGCAGAU GUUUCCACGTA-3′。所述RALA基因的小干扰RNA可用于制备抗白血病的药物。本发明RALAsiRNA可以通过下调癌基因RALA的表达抑制人白血病k562细胞生长，对肿瘤基因治疗具有潜在的应用价值，有望将其应用于白血病的治疗，并在此基础之上，开发抗白血病新药，为临床白血病的防治做出贡献。
摘要（英）：

The invention discloses a small interfering RNA (Ribonucleic Acid) of an RALA (v-ral simian leukemia viral oncogene homolog A) gene and application thereof in preparing medicaments for resisting leukemia. The sequence of the small interfering RNA is as follows: the positive-sense strand is 5'-CGUGGAAACAUCUGCUAAATT-3', and the antisense strand is 5'-UUUAGCAGAU GUUUCCACGTA-3'. The small interferingRNA of the RALA gene can be used for preparing the medicaments for resisting the leukemia. The RALAsiRNA can suppress the growth of human leukemia k562 cells through down regulating the expression of a cancer RALA, has potential application values to oncogene treatment and is expected to be applied to the treatment of the leukemia. Moreover, on the basis of the small interfering RNA, new medicines for resisting the leukemia are developed to make a contribution to the prevention and cure of clinical leukemia.

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