The invention relates to an active control method of the main reflecting surface of a 65-meter radio telescope. The invention is characterized in that the main surface is a combined main surface formed by splicing a plurality of subpanels, each subpanel is controlled by a plurality of actuators, and a control system respectively controls the actions of all the actuators, i.e. the main surface is divided into eight sectors, and the actuators in each sector are used as a control set; each control set is provided with a sector controller; initialization is carried out after starting up, and the actuator controllers await orders; a main controller analyzes control commands and sends control values of the actuators through a local area network, i.e. a 24-port fiber switch is respectively connected with the sector controllers and sends the commands; each sector carries out operation to obtain the magnitude of force to be applied to each actuator; the commands are sequentially sent to microcontrollers of each actuator; each actuator controller returns state information of execution after executing the commands; and a server of the sector controllers sends all the returned information to the main controller. The invention can meet the technical requirement on more complication and higher precision of the 65-meter radio telescope.