The invention discloses an alpha-asarone spraying agent and a preparation method thereof. The alpha-asarone spraying agent is prepared from the following raw materials in parts by weight: alpha-asarone, a cosolvent, a stabilizer, a correctant, a bacteriostat and a solvent. The preparation method comprises the following steps: A. mixing, stirring and dissolving the cosolvent, the stabilizer, the correctant, the bacteriostat and the solvent; B. adding the alpha-asarone in the formula to solution in step A, and then stirring for dissolution; and C. filtering the solution in step B, filling according to 50ml/bottle, and then sealing to obtain the alpha-asarone spraying agent. The preparation method has simple and feasible preparation procedures, convenient operation, good product uniformity, strong quality control operability and stable product quality under a storage condition; and the method effectively solves the problems of low bioavailability and great toxic and side effects of asarone oral liquid and injection. The alpha-asarone spraying agent has convenient use and fast efficacy, and can be widely applied to anti-inflammation, relieving cough, eliminating phlegm and relieving asthma, tranquilizing, spasmolysis and epileptic seizure clinically.