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发明公开
CN101885751A 一种地索奈德的合成方法 无效 - 撤回

一种地索奈德的合成方法
摘要：
本发明公开了一种结构如式(III)所示的地索奈德的合成方法，所述的合成方法包括如下步骤：将如式(I)所示的16α-羟基氢化泼尼松与丙酮加到如式(II)所示的酸性离子液体中，在10～100℃的温度下充分反应，所得反应液经后处理即得到地索奈德；式(II)中，R为C1～C10的取代烷基，所述取代烷基的取代基为磺酸基或羧基，L为HSO4、COO、CH3COO、BF4、PF6、AlCl4或CF3SO3；或者R为C1～C10的烷基，L为HSO4、COO、AlCl4或CF3SO3。本发明技术易操作，收率高，三废少，后处理方便，离子液体可重复使用，是经济实用的绿色环保技术。
摘要（英）：

The invention discloses a method for synthesizing desonide with a structure in a formula (III). The method for synthesizing the desonide comprises the following steps of: adding 16alpha-hydroxyhydrogenated prednisone shown in a formula (I) and acetone into acidic ionic liquid shown in a formula (II), fully reacting at the temperature of between 10 and 100 DEG C, and aftertreating the obtained reaction liquid to obtain the desonide. In the formula (II), R is substituted C1-C10 alkyl, the substituent group of the substituted alkyl is sulfo or carboxyl, and L is HSO4, COO, CH3COO, BF4, PF6, AlCl4 or CF3SO3; or R is C1-C10 alkyl, and L is HSO4, COO, AlCl4 or CF3SO3. The method for synthesizing the desonide has the advantages of easy operation, high yield, low three wastes, convenient aftertreatment, and repeatedly used ionic liquid, and is economic and practical environment-friendly technology.

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