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发明公开
CN101890000A 藤黄酸作为热休克蛋白90抑制剂的用途 无效 - 驳回

藤黄酸作为热休克蛋白90抑制剂的用途
摘要：
藤黄酸作为热休克蛋白90抑制剂的用途。涉及藤黄酸，提供藤黄酸在制备热休克蛋白90抑制剂中的应用。所述藤黄酸的名称为(z)-甲基-3-戊烯基)-；1，5-二亚甲基-1，3，11-三氢-呋喃并(3，4-g)吡喃并(3，2-b)蒽酮-1-巴豆酸，分子式为C38H44O8，旋光度为-685°，不易溶于水，在甲醇等有机溶剂中有较好的溶解性。所述藤黄酸能够抑制热休克蛋白90的ATP酶活性，降解热休克蛋白90的客户蛋白，在制备治疗各种因热休克蛋白90活性异常引起的疾病的药物上具有广泛的应用。
摘要（英）：

The invention discloses the application of gambogic acid as an inhibitor of heat shock protein 90, relates to the gambogic acid and provides the application of the gambogic acid in preparing the inhibitor of the heat shock protein 90. The name of the gambogic acid is (z)-methyl-3-pentenyl)-; 1,5-dimethylene-1,3,11-trihydrotris-furo (3,4-g) pyrano (3,2-b) anthranone-1-crotonic acid, the molecular formula of the ambogic acid is CH38H44O8, the optical activity of the ambogic acid is minus 685 degrees, the gambogic acid is insoluble in water and well soluble in organic solvents such as methyl alcohol and the like. The gambogic acid is capable of inhibiting the ATP enzymatic activity of the heat shock protein 90 and degrading the client protein of the heat shock protein 90, and has wide application in preparing drugs for treating various diseases caused by the abnormal activity of the heat shock protein 90.

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