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发明公开
CN101891687A 乏氧显像剂18F-氟咪索硝唑的合成方法 无效 - 撤回

乏氧显像剂18F-氟咪索硝唑的合成方法
摘要：
本发明提供了乏氧显像剂18F-氟咪索硝唑(18F-FMISO)的合成方法。其以NITTP作为前体，经亲核取代和水解两步来合成FMISO，所述方法中利用了经过改进的CTI公司生产的双管18F-FDG合成模块来进行FMISO的放射性合成。所述方法对各项参数进行调整和改进(如调整反应时间、反应温度、转移时间及蒸发时间等)，用[18F]KF/K222作为氟化剂，经过亲核氟化和酸水解两步反应自动化合成18F-FMISO。本发明的放射合成方法相比于现有技术的方法缩短了反应时间，提高了放化收率。
摘要（英）：

The invention provides a method for synthesizing hypoxia imaging agent 18F-FMISO. In the method, NITTP is taken as a precursor, the FMISO is synthesized through nucleophilic substitution and hydrolysis, and an improved double-tube 18F-FDG synthesis module produced by CTI (CNetTechnologyInc) is used for carrying out radio-synthesis of the FMISO. In the method, parameters are adjusted and improved (such as adjusting reaction time, reaction temperature, transfer time, evaporation time, and the like), [18F]KF/K222 is taken as a fluorinating agent, and the 18F-FMISO is automatically synthesized through nucleophilic fluorination and acid hydrolysis. Compared with the prior art, a radio-synthesis method shortens the reaction time and improves the radiochemical efficiency.

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