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发明公开
CN101891692A 高哌嗪的制备方法 无效 - 撤回

高哌嗪的制备方法
摘要：
本发明一种高哌嗪的制备方法，包括以下步骤：第一步，将乙二胺与甲酰化试剂回流反应，得到N-（2-甲酰基乙基）甲酰胺，乙二胺与甲酰化试剂的摩尔比为1∶2～4；第二步，将N-（2-甲酰基乙基）甲酰胺，在碱性条件下，与1,3-二卤代丙烷反应，得到1,4-二甲酰基高哌嗪，N-（2-甲酰基乙基）甲酰胺与1,3二卤代丙烷的摩尔比为1∶1.0～1.2；第三步，1,4-二甲酰基高哌嗪在盐酸醇溶液中，脱甲酰基得到高哌嗪。本发明采用原料便宜；合成工艺简单，上保护去保护条件温和；工艺条件温和，设备简单；整个过程中用到的溶剂均易于回收再利用。
摘要（英）：

The invention discloses a preparation method of homopiperazine, comprising the following steps of firstly, obtaining N-(2-formylethyl) formamide by carrying out reflux reaction on ethylenediamine and formylation reagent, wherein the molar ratio of the ethylenediamine to the formylation reagent is 1:2-4; secondly, obtaining 1,4-dicarboxy homopiperazine by reacting the N-(2-formylethyl) formamide with 1,3-propane dihalide under the alkaline condition, wherein the molar ratio of the N-(2-formylethyl) formamide to the 1,3-propane dihalide is 1:1.0-1.2; and thirdly, obtaining the homopiperazine by removing formyl of the 1,4-dicarboxy homopiperazine in alcohol hydrochloride solution. The invention has the advantages of cheap raw materials, simple synthesis technology, mild protection conditions, mild technological conditions, simple equipment and easy recovery and reuse of used solvent in the whole process.

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