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发明授权
CN101891870B 一种具有pH响应性的两亲性共聚物刷及其制法和应用 失效 - 权利终止

一种具有pH响应性的两亲性共聚物刷及其制法和应用
摘要：
本发明公开了一种pH响应两亲性共聚物刷及其制备方法。具体公开了一种由疏水基团和pH响应基团共聚的嵌段与亲水刷状嵌段组成的pH响应两亲性共聚物刷。本发明通过原子转移自由基聚合(ATRP)得到疏水性单体与pH响应功能性单体的共聚体，然后以此作为大分子引发剂，对亲水性大分子单体甲基丙烯酸单甲氧基聚乙二醇酯(PEGMA)进行ATRP聚合，再经过选择性水解反应，制得pH响应两亲性共聚物刷。本发明的制备方法工艺简单，产率较高。所合成的pH响应两亲性共聚物刷结构新颖，且功能基团比例可调控。适用于难溶性药物的包载传输。
摘要（英）：

The invention discloses an amphiphilic copolymer brush with pH responsiveness and a preparation method thereof. Particularly, the invention discloses an amphiphilic copolymer brush with pH responsiveness comprised of a block, which is formed by the copolymerization of a hydrophobic group and a pH response group, and a hydrophilic brush-shaped block. In the invention, a copolymer of a hydrophobic monomer and a pH response functional monomer is obtained by atom transfer radical polymerization (ATRP), then the copolymer is used as a macromolecular initiator to perform the ATRP polymerization of monomethoxypoly (ethylene glycol) methacrylate (PEGMA) which is a hydrophilic macromolecular monomer, and finally, a selective hydrolysis reaction is performed to prepare the amphiphilic copolymer brush with pH responsiveness. The preparation method of the invention has the advantages of simple process and high yield. The synthesized amphiphilic copolymer brush with pH responsiveness has a novel structure and an adjustable functional group proportion, and is suitable to be used in the transmission of entrapped insoluble medicaments.

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