The invention provides an application of sodium dodecyl benzene sulfonate in preparing external medicines of rabbit sarcopticacariasis, and the medicine is an ointment. The application is as follows: mixing and processing 2% of sodium dodecyl benzene sulfonate powder by weight with 9% of stearic acid by weight, 3% of glycerine by weight, 1% of setanol by weight, 1% of octadecanol by weight, 1% of atoleine by weight, 10% of wool grease by weight, 64.5% of distilled water by weight, 8% of glycerol by weight and 0.5% of triethanolamine by weight to obtain the sodium dodecyl benzene sulfonate ointment, and then subpackaging into ointment with the specification of 20g, wherein the preparation process of the 2% sodium dodecyl benzene sulfonate ointment comprises the following steps: adding glycerol into the distilled water according to the ratio, and heating to 85DEG C, keeping the water temperature; preparing into water phase; mixing the stearic acid, the glycerine, the setanol, the octadecanol, the atoleine, the wool grease and the sodium dodecyl benzene sulfonate into the same container; placing on a water bath to heat and melt, and keeping the dissolving state to prepare into oil phase; adding the water phase slowly into the oil phase and stirring in the same direction at the same time; simultaneously adding the triethanolamine for emulsification; and cooling and solidifying to obtain the ointment.