The invention discloses an intelligent guide man-machine interaction device. The device comprises a master controller, wherein a 16-bit microprocessor is adopted by the master controller to control that a main circuit is connected with a wireless module through a 232 serial port; the master controller is connected with an earphone microphone through an audio input port, connected with an earphone headphone through an audio output port, connected with a guide robot through a rope induction tension detection device and connected with a vibration inductor by a drive; and an interruption input port of the master controller is connected with braille touch keys. The device has the advantages of voice recognition and broadcasting, wireless command transmission, rope tension induction, vibration inductor output and the like, can ensure a proper safety driving distance with the guide robot by realizing man-machine interaction through the voice induction and the vibration induction, increases the use safety and interaction convenience of a handhold device, effectively solves the problem of man-machine interaction of the intelligent guide robot under outdoor environment and has high application value.