利索-全球专利检索

  1. 登录
  2. 注册
发明公开
CN101993405A 吲哚啉衍生物、及其制备方法和用途 有权 转让

吲哚啉衍生物、及其制备方法和用途
摘要：
本发明提供了1-(3-保护基羟丙基)-5-((2R)-2-(2-(2-(2，2，2-三氟乙氧基)苯氧)乙胺基)丙基)吲哚啉-7-氰基制备方法及具体化合物结构(Ia)所示的1-(3-(4-氟苯甲酰基)羟丙基)-5-((2R)-2-(2-(2-(2，2，2-三氟乙氧基)苯氧)乙胺基)丙基)吲哚啉-7-氰基。该方法特征在于以水为溶剂，收率高。具体化合物结构(Ia)所示的1-(3-(4-氟苯甲酰基)羟丙基)-5-((2R)-2-(2-(2-(2，2，2-三氟乙氧基)苯氧)乙胺基)丙基)吲哚啉-7-氰基可作为中间体应用于吲哚啉衍生物的制备，本发明的方法操作简单，收率高。
摘要（英）：

The invention provides a preparation method of 1-(3-protecting propyl)-5-((2R)-2-(2-(2-(2,2,2-trifluoroethyoxyl)phenoxy)ethylamine)propyl)indoline-7-cyan and 1-(3-(4-flurobenzoyl)hydroxyl propyl)-5-((2R)-2-(2-(2-(2,2,2-trifluoroethyoxyl)phenoxy)ethylamine)propyl)indoline-7-cyan shown as in a specific compound structure (Ia) in the specification. The method is characterized in that water is used as a solvent and the yield is high. The 1-(3-(4-flurobenzoyl)hydroxyl propyl)-5-((2R)-2-(2-(2-(2,2,2-trifluoroethyoxyl)phenoxy)ethylamine)propyl)indoline-7-cyan shown as in the specific compound structure (Ia) can be used as an intermediate to be applied to the preparation of an indoline derivative. The method of the invention is simple in operation and high in yield. IIa R=4-FC6H4COIb R=C6H5COIc R=C6H5CH2

公开/授权文献
0/0