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发明公开
CN102000050A 一种改善溶出性能的尼美舒利药物组合物及其制备方法 有权

一种改善溶出性能的尼美舒利药物组合物及其制备方法
摘要：
本发明提供一种改善溶出性能的尼美舒利的药物组合物及其制备方法。本发明的药物组合物由下列重量百分配比的组分组成：尼美舒利1％-30％、分散剂(液体聚乙二醇的一种或多种)5％-30％、稀释剂(微晶纤维素、乳糖和淀粉中的一种或多种)60％-85、二氧化硅1％-10％、崩解剂(羧甲淀粉钠)2％-20％、粘合剂(羟丙甲纤维素)0.1％-5.0％。本发明的尼美舒利组合物溶出度在5分钟-10分钟内可达到90％以上，甚至高达100％，这与各种药物的常规固体组合物不同，提高了尼美舒利的生物利用度，有利于临床用于快速退热或镇痛，具有较大的应用价值。
摘要（英）：

The invention provides a nimesulide medicine composition for improving dissolution performance and a preparation method thereof. The medicine composition in the invention comprises the following components in weight percentage: 1%-30% of nimesulide, 5%-30% of dispersing agent (at least one kind of liquid polyethylene glycol), 60%-85% of diluent (one or more of microcrystalline cellulose, lactose and starch), 1%-10% of silicon dioxide, 2%-20% of disintegrating agents (carboxymethyl starch sodium) and 0.1%-5.0% of adhesives (hydroxypropyl methylcellulose). The dissolution degree of the nimesulide medicine composition can reach above 90% within 5-10 minutes, and even 100%, thus the nimesulide medicine composition is different from the conventional solid composition of various medicines; and the nimesulide medicine composition improves the bioavailability of the nimesulide, is beneficial to clinical rapid fever abatement or pain killing and has high application value.

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