The invention relates to the field of comprehensive utilization of oil shale, and provides a comprehensive utilization method of oil shale. Particularly, in the method, hydrogen production and oil hydrogenation processes of synthesis gas generated by oil shale dry distillation, dry distillation semicoke pre-charking, semicoke gasification after pre-charking, heavy oil recycle and gasification areorganically combined so as to obtain oil products from raw materials to the maximum extent, the oil products are hydrotreated to obtain high-quality clean oil products, the synthesis gas generated bygasification can be used as high-quality and cheap raw material for hydrogen production to provide a hydrogen source for oil product hydrogenation, and oil shale ash products obtained by cooling after gasification and complementary calcination are used as high-quality building materials. The invention provides a comprehensive utilization cleaner production process which can convert raw materials into high-quality products to the maximum extent and can fully utilize semicoke resources and rich production energy.