The invention discloses a zero-point calibration method for a hot continuous rolling machine frame. In the method, the current gap between rollers is smaller than the sum of the maximum extension length of an oil cylinder piston and the maximum bouncing value of the machine frame; an upper roller and a lower roller approach to each other through a position closed-loop system of a pressing position controller; the pressing position controller is automatically switched into a pressure closed-loop state; the rollers are continuously pressed under the pressure closed-loop by a method for progressively increasing a small rolling force every time; the average rolling force and roller gap on the two side in the time period are calculated; the pressing position controller is automatically switched to a position closed-loop state; and the rollers are moved downwards while the roller gap difference is kept until the zero-point calibration is completed and the rollers are uplifted. In the method, the rollers are leveled once before the zero-point force pressing, so that the balance state during the zero-point calibration is improved; and a circulation of the roller balance test and recalibration at the zero-point position is added after the first zero-point force pressing process is finished, so that the balance state of the rollers at the zero-point position is guaranteed.