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发明公开
CN102050775A 阿那曲唑杂质α,α,α′,α′-四甲基-5-(丁二酰亚胺-1-基甲基)-1,3-苯二乙腈及其制备方法 有权 许可

阿那曲唑杂质α,α,α′,α′-四甲基-5-(丁二酰亚胺-1-基甲基)-1,3-苯二乙腈及其制备方法
摘要：
本发明公开了一种α，α，α′，α′-四甲基-5-(丁二酰亚胺-1-基甲基)-1，3-苯二乙腈式I及其制备方法。本发明通过(1)化合物IV与N-溴代丁二酰亚胺反应合成3，5-二[(2，2-二甲基)氰基甲基溴甲苯(III)；(2)化合物III与1，2，4-三氮唑反应，经后处理得到化合物I。本发明方法有效，简便，宜于工业化生产应用。
摘要（英）：

The invention discloses an alpha, alpha, alpha', alpha'-tetramethyl-5-(succinimide-1-methyl)-1,3-phenyl diacetonitrile formula I and a preparation method thereof. The method comprises the following steps of: (1) reacting a compound IV and N-bromosuccinimide to synthesize 3,5-di[(2,2-dimethyl) cyanomethylbromotoluene (III); and (2) reacting the compound III with 1,2,4-triazole, and obtaining a compound I by post treatment. The method is effectively, simple and convenient, and is suitable for industrialized production and application.

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