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发明公开
CN102050872A 在结肠癌组织中高表达的标记物HCCR-1蛋白及结肠癌预后标志物 无效 - 撤回

在结肠癌组织中高表达的标记物HCCR-1蛋白及结肠癌预后标志物
摘要：
一种在结肠癌组织中高表达的标记物HCCR-1蛋白及结肠癌预后标志物。解决采用现有结肠癌预后监测中常用的肿瘤标志物进行预后评估仍不准确的问题。本发明提供的在结肠癌组织中高表达的标记蛋白HCCR-1蛋白，是编码为序列表SEQ ID NO：1所示的氨基酸序列组成的蛋白。该标记蛋白还可以是以上所限定的氨基酸序列中经过取代、缺失或添加一个或几个氨基酸且具有在结肠癌组织中高表达活性的蛋白及其片段。本发明还提供了一种结肠癌预后标志物，该标志物包括以上所述的在结肠癌组织中高表达的标记蛋白HCCR-1蛋白，以及该标志物还可以包括选自但不限于EGFR、VEGF、COX-2基因型或蛋白的一种或多种药剂。
摘要（英）：

The invention discloses a marker HCCR-1 protein highly expressed in colon cancer tissue and a prognostic marker for colon cancer and solves the problem of inaccuracy of prognostic evaluation carried out by adopting a cancer marker which is commonly used in the conventional colon cancer prognostic monitoring. The marker HCCR-1 protein highly expressed in the colon cancer tissue is a protein coded by an amino acid sequence shown by SEQ ID No. 1 in the sequence list. The marker protein can also be a protein with high expression activity in the colon cancer, which is obtained by substituting, losing or adding one or several amino acids in the limited amino acid sequence, and segments thereof. The invention also provides a prognostic marker for the colon cancer, which comprises the marker HCCR-1 protein highly expressed in the colon cancer tissue, and one or more medicaments selected from but not limited to EGFR, VEGF and COX-2 genes and proteins.

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