The invention relates to an arginine salt compound of derivatives (compounds D) of dibasic ester acids, which comprises dibasic arginine, monobasic arginine, hydrates or solvates thereof. The arginine salt compound has good water solubility and stability and eliminates the adverse reactions such as vessel stimulation, muscle stimulation and the like when the metal salt of the arginine salt compound is used for injection. The invention also provides a preparation method and medicinal application of the arginine salt compound.