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发明授权
CN102083845B 环丙基聚合酶抑制剂 失效 - 权利终止 复审申请

环丙基聚合酶抑制剂
摘要：
一种式I化合物：其中：R2为氢或C1‑C4烷基；R3和R4为独立地选自氢、‑C(=O)R5和‑C(=O)CHR6‑NH2组成的群；或R3为氢和R4为单磷酸酯、二磷酸酯或三磷酸酯；或R3为氢、‑C(=O)CHR5或‑C(=O)CHR6‑NH2和R4为（式2），各R5独立地选自氢、C1‑C6烷基和C3‑C7环烷基的群；R6为氢或C1‑C6烷基；R7为任选经取代的苯基、萘基、或吲哚基；R8和R8’为氢、C1‑C6烷基、苄基；或R8和R8’合并形成C3‑C7环烷基；R9为C1‑C6烷基、苄基或任意经取代的苯基；条件是R2、R3和R4不均为氢；或其药学上可接受的盐类或溶剂合物；具化合物I的药物配制剂；化合物I作为HCV抑制剂的用途，包括其中R2、R3和R4均为氢的式I化合物。
摘要（英）：

Compounds of formula I: wherein: R 2 is hydrogen or C 1 -C 4 alkyl; R 3 and R 4 are hydrogen, -C(=O)R 5 , or -C(=O)CHR 6 -NH 2 ; or R 3 is hydrogen and R 4 is a monophosphate-, diphosphate-, or triphosphate ester; or R 3 is hydrogen, -C(=O)CHR 5 , or -C(=O)CHR 6 -NH 2 and R 4 is each R 5 is hydrogen, C 1 -C 6 alkyl, or C 3 -C 7 cycloalkyl; R 6 is hydrogen or C 1 -C 6 alkyl; R 7 is optionally substituted phenyl; naphthyl; or indolyl; R 8 and R 8' are hydrogen, C 1 -C 6 alkyl, benzyl; or R 8 and R 8' combined form C 3 -C 7 cycloalkyl; R 9 is C 1 -C 6 alkyl, benzyl, or optionally substituted phenyl; provided that R 2 , R 3 and R 4 are not all hydrogen; or a pharmaceutically acceptable salt or solvate thereof; pharmaceutical formulations with the compounds I; the use of compounds I, including the compounds of formula I wherein R 2 , R 3 and R 4 are all hydrogen, as HCV inhibitors.

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