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发明公开
CN102089431A 官能化的多肽 无效 - 驳回 复审申请

官能化的多肽
摘要：
本发明提供官能化的多肽，尤其是治疗性多肽(例如，scFv)，其包括可通过添加一个或官能部分(例如，PEG)或结合特异性(例如，有特定结合特异性的氨基酸序列)来快速及特异性地官能化的接头序列。所述官能化的多肽的优点在于，它们相比非官能化的多肽具有改善的药代动力学性质(例如，改善的体内半衰期，组织渗透及组织停留时间)。还提供了快速及可再现产生官能化的多肽的方法。
摘要（英）：

The invention provides functionalized polypeptides, especially therapeutic polypeptides (e.g., scFv), comprising a linker sequence that can be rapidly and specifically functionalized by the addition of one or functional moieties (e.g., PEG) or binding specificities (e.g., an amino acid sequence with a particular binding specificity). Such functionalized polypeptides are advantageous in that they have improved pharmacokinetic properties (e.g., improved in vivo half-life, tissue penetration and tissue residency time) over non-functionalized polypeptides. Methods for the rapid and reproducible generation of functionalized polypeptides are also provided.

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