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发明公开
CN102093468A 还原型谷胱甘肽的合成方法 失效 - 权利终止

还原型谷胱甘肽的合成方法
摘要：
本发明涉及一种还原型谷胱甘肽的合成方法，其步骤：⑴、R-谷氨酸的制备；⑵、R-谷氨酸酐的制备；⑶、R-谷氨酸-α-苄酯的制备；⑷、R-谷氨酸-α-苄酯-γ-酰氯的制备；⑸、R-谷氨酸-α-苄酯-胱氨酸的制备；⑹、甘氨酸-苄酯盐酸盐的制备；⑺、双R-S-S-谷胱甘肽-四苄酯的制备：⑻、还原型谷胱甘肽的制备。本发明工艺步骤简单环保，缩短了合成步骤，提高了收率，而且所用原材料成本较低，是一种创新性较高的还原型谷胱甘肽的合成方法。
摘要（英）：

The invention relates to a method for synthesizing reduced glutathione. The method comprises the following steps of: (1), preparing R-glutamic acid; (2), preparing R-glutamic anhydride; (3), preparing R-glutamic-alpha-benzyl ester; (4), preparing R-glutamic-alpha-benzyl ester-gamma-acyl chloride; (5), preparing R-glutamic-alpha-benzyl ester-cystine; (6) preparing glycine-benzyl ester hydrochloride; (7) preparing bisR-S-S-glutathione-tetrabenzyl ester; and (8), preparing the reduced glutathione. The method has a simple and environmentally-friendly process step; the synthesizing steps are shortened; the yield is improved; and the used raw materials have relatively low cost. The method is the method for synthesizing the reduced glutathione, which has relatively high innovativeness.

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