The invention discloses an autonomous examination and approval method based on a distributed database. The method comprises steps as follows: deploying a My SQL database on a database server of every mechanism, and the database servers of all mechanisms are connected into a distributed network through the Internet or Intranet; and adopting an open source database intermediate piece to establish and change the My SQL database into a distributed database with an unified access interface, and establish an autonomous examination and approval system on the basis of the distributed database. While relieving the pressures of computation and storage of a WEB and a database server responsible for examination and approval service, the invention limits the storage and access of confidential information in project examination and approval data in the mechanism and inter-mechanism examination and approval to the mechanism thereof, thereby ensuring each mechanism to have a rather autonomous examination and approval right during internal and joint examination and approval.