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发明公开
CN102140117A 1,4,6,10-四双键十五碳膦酸酯及其制备方法以及制备番茄红素方法 有权

1,4,6,10-四双键十五碳膦酸酯及其制备方法以及制备番茄红素方法
摘要：
本发明提供了一种式(4)的1，4，6，10-四双键十五碳膦酸酯及其制备方法，该制备方法包括：将式(2)的假紫罗兰酮与锍鎓盐反应制备得到式(9)的环氧化物，然后该式(9)的环氧化物与溴化镁反应制备得到式(3)的C-14醛；将式(3)的C-14醛与亚甲基二膦酸四烷基酯进行缩合反应制备得到式(4)的1，4，6，10-四双键十五碳膦酸酯。另外，本发明还提供了式(4)的1，4，6，10-四双键十五碳膦酸酯制备式(1)的番茄红素的方法。本发明的方法具有工艺路线简捷、原料易得、成本低的优点。
摘要（英）：

The invention provides 1, 4, 6, 10-tetra-double bond pentadec-carbon phosphonate of a formula (4) and a preparation method thereof. The preparation method comprises: reacting pseudoionone of a formula (2) and sulfonium salt to obtain an epoxide of a formula (9); reacting the epoxide of the formula (9) with magnesium bromide to obtain C-14 aldehyde of a formula (3); and performing the condensation reaction of the C-14 aldehyde of the formula (3) and tetraethylmethylenediphosphonate to obtain the 1, 4, 6, 10-tetra-double bond pentadec-carbon phosphonate of the formula (4). In addition, the invention also provides a method for preparing lycopene by using the 1, 4, 6, 10-tetra-double bond pentadec-carbon phosphonate of the formula (4). The methods provided by the invention have the advantages of simple process, readily available raw material and low cost.

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