The invention relates to a high-head fall-off ore pump transportation pipeline which extends along a mountain from high to low. The transportation pipeline is composed of a plurality of fall-off pipelines and a plurality of energy dissipation pipelines; the plurality of fall-off pipelines are fixed on the mountain along the tendency of the mountain from high to low; any adjacent two fall-off pipelines are communicated through the energy dissipation pipeline; and one end of the energy dissipation pipeline is connected to the upper end of each fall-off pipeline at a low position, and the other end of the energy dissipation pipeline is connected to the lower end of each fall-off pipeline at a high position. According to the invention, because the transportation pipeline is provided with the fall-off pipelines and the plurality of energy dissipation pipelines which are connected alternatively, the descending speed of ore pulp of iron ore concentrate by the transportation pipeline, thus the kinetic energy of the iron ore concentrate falling off from high to low is reduced, the use of an energy dissipation device is saved, and the cost is saved, and the working efficiency is improved.