The invention discloses compound lychee seed hpyerglycemic particles, which comprise the following components in parts by weight: 25-80 parts of lychee seed total saponin powder, 25-80 parts of mulberry leaf total alkaloid powder, 750-950 parts of loading agent and 1-5 parts of flavoring agent. The invention further discloses a preparation method of the compound lychee seed hpyerglycemic particles. In the compound lychee seed hpyerglycemic particles, lychee seeds produced in the lychee processing process and by-produced mulberry leaves in the silkworm and mulberry industry are taken as major raw materials for preparing lychee seed total saponin powder and mulberry leaf total alkaloid powder which are prepared into particles together with pharmaceutically acceptable auxiliary materials. Due to the medicinal complementary properties of the lychee seed total saponin powder and the mulberry leaf total alkaloid powder, the problem that a single medicinal material is too cold or too warm can be solved; meanwhile, the two medicinal materials have hpyerglycemic functions, so that a better hpyerglycemic effect can be achieved when the two medicinal materials are under together. The compound lychee seed hpyerglycemic particles have a good hpyerglycemic effect, and can be applied to auxiliary hpyerglycemic treatment of non-insulin dependent diabetes patients.