The invention discloses a refining method of a Tenatoprazole salt. The refining method comprises the following steps: adding a crude Tenatoprazole salt and methanol to a dissolving bottle, heating with stirring to dissolve the solid Tenatoprazole salt; adding active carbon to decolorize, and filtering; and carrying out vacuum condensation on a filtrate until turbidity, adding ethyl acetate to crystallize, and filtering, washing, drying crystals obtain a medicinal grade Tenatoprazole salt. The refining method of the invention which has the advantage of safety because of reduction of the explosion danger, and also has the advantage of economy because of easy recovery and reuse of solvents adopted in the invention is suitable for industrial production. The Tenatoprazole salt prepared in the invention has the advantages of high yield, high purity, low solvent residual, good color, and good stability.