The invention discloses a production method of a high-performance titanium alloy blind pipe. The production method comprises the following steps of: (a) coating a graphite coating on the surface of a core bar; (b) placing the core bar in a sheath cylinder and clamping the core bar at the centre of the sheath cylinder by using a core bar positioning tool; fixing the bottom end of the core bar on asheath bottom cover, and welding the sheath bottom cover at the bottom end of the sheath cylinder; and then filling titanium alloy powder into a cavity which is formed by the sheath cylinder and the core bar; (c) welding a sheath top cover at the top of the sheath cylinder, reserving a space for placing a degasification pipeline, and vacuumizing the sheath cylinder; (d) fixing both ends of a sheath in a sheath hot isostatic pressing tool, and carrying out a thermal isostatic pressing process; (e) taking out the sheath, fixing both ends of the sheath on a hydraulic machine, and drawing out thecore bar in the sheath; and (f) machining the core bar to obtain the titanium alloy blind pipe. According to the production method provided by the invention, because the core bar can be rapidly removed, the final size of the prepared high-performance thin and long titanium alloy blind pipe can be reached without machining an inner cavity, therefore, the production period is short, the yield is high, and the product performance and the internal quality are stable and reliable.