The invention discloses synthesis method of biphenyl liquid crystal with end group containing epoxy group. The method comprises the following steps of: dissolving 2-10g of chemical pure 4,4'-bis(beta-hydroxyethoxy)biphenyl in 10-80ml of analytical pure N,N-dimethylformamide with molar concentration of l mol/L; dissolving 0.5-4.0g of analytic pure sodium hydroxide in 1-10ml of water; mixing the two solutions and dissolving in a 250ml three-neck flask; heating to 90 DEG C and reacting for 0.5-2 hours; adding dropwise 5-50g of analytic pure epoxy chloropropane with molar concentration of l mol/L; adding 0.01-1g of analytic pure tetra-n-butyl ammonium bromide serving as a catalyst; heating to 110 DEG C; stirring for backflow for 4-12 hours; after the reaction is over, cooling to room temperature; washing with a great amount of water and absolute ethyl alcohol for 2-3 times; and filtering to obtain white powder. In the invention, the raw materials are widely available, the cost is low and less pollution is caused; the synthesis process is relatively simple, and the synthesis time is short; and the synthesized liquid crystal with end group containing epoxy group has the advantages of relatively wide liquid crystal region and good liquid crystal state, as well as wide application scope.