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发明公开
CN102392039A HIV-1B亚型耐药突变株及其构建方法和应用 无效 - 驳回

HIV-1B亚型耐药突变株及其构建方法和应用
摘要：
本发明公开了一种HIV-1B亚型耐药突变株及其构建方法和应用。本发明提供的的方法，是将HIV-1B亚型野生株的逆转录酶自N末端第369位氨基酸残基由苏氨酸突变为缬氨酸，获得HIV-1B亚型耐药突变株。本发明对于抗HIV药物的筛选具有重大价值，进而对艾滋病的治疗具有深远影响。
摘要（英）：

The present invention discloses an HIV-1B subtype drug-resistant mutant and a construction method and application thereof. In accordance with the method provided by the present invention, the reverse transcriptase of an HIV-1B subtype wild strain is mutated from threonine to valine from the 369th amino acid residue at the N tail end, so as to obtain an HIV-1B subtype drug-resistant mutant. The present invention is significant for the sifting of HIV-resistant drugs, thereby having far-reaching influence on the cure of AIDS.

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