The invention relates to a closed cooling and waste heat utilization process for epoxy compound sewage. Epoxy compound raw water is adjusted and pumped into a fiber filter loaded with a soft filler, the suspended solid (SS) value of water discharged by the filter is controlled in a certain range, and the water is taken as primary water of a full-automatic heat exchange unit and fed into a heat exchanger; meanwhile, the pretreated sewage or clean water is taken as secondary side inlet water; after the sewage is subjected to heat exchange by the full-automatic heat exchange unit, the temperature of the epoxy compound sewage is reduced to a range which can be tolerated by mesophilic bacteria in biochemical treatment, and secondary side sewage is heated to a water inlet temperature required by an anaerobic treatment device; and if the clean water is adopted, the produced hot water can be used as boiler make-up water, domestic hot water, heating and air conditioning hot water and the like according to the water quality of the clean water. The process has the characteristics of capability of effectively utilizing waste heat energy, no secondary pollution, continuous and stable operation, low overhaul and maintenance cost and the like.