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发明公开
CN102464661A 一种5,6,7,8-四氢-咪唑并[1,5-a]吡嗪-1-羧酸乙酯的制备方法 有权 转让

一种5,6,7,8-四氢-咪唑并[1,5-a]吡嗪-1-羧酸乙酯的制备方法
摘要：
本发明涉及一种5,6,7,8-四氢-咪唑并[1,5-a]吡嗪-1-羧酸乙酯衍生物的制备方法，主要解决现有合成方法存在收率不高，难纯化，实验操作不便等技术问题，本发明包括以下步骤（1）：2-甲硫基吡嗪的制备；（2）：甲硫基的氧化；（3）：甲基砜基的关环；（4）：吡嗪的氢化还原。反应式如下：，本发明获得的5,6,7,8-四氢-咪唑并[1,5-a]吡嗪-1-羧酸乙酯-衍生物为许多药物合成的有用中间体或产品。
摘要（英）：

The invention relates to a preparation method of a 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid ethyl ester derivative, mainly aiming at solving the technical problems of low yield, difficulty in purifying, inconvenience for experimental operation and the like existing in the conventional synthesis method. The preparation method comprises the following steps of: (1) preparing 2-methylthiopyrazine; (2) oxidizing methylthio; (3) closing a ring of methyl sulfuryl; and (4) hydrogenating and reducing pyrazine. A reaction formula is shown in the specifications. The 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid ethyl ester derivative obtained by utilizing the preparation method disclosed by the invention is a useful intermediate or product synthesized by multiple medicaments.

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