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发明公开
CN102470134A 药物组合物和固体形式 无效 - 撤回

药物组合物和固体形式
摘要：
本发明涉及6-(6-羟基甲基-嘧啶-4-基氧基)-萘-1-甲酸(3-三氟甲基-苯基)-酰胺的药物组合物，涉及6-(6-羟基甲基-嘧啶-4-基氧基)-萘-1-甲酸(3-三氟甲基-苯基)-酰胺以及6-(6-羟基甲基-嘧啶-4-基氧基)-萘-1-甲酸(3-三氟甲基-苯基)-酰胺的组合物在治疗应用尤其是与VEFG失调/过表达、(新生)血管形成和VEGF驱动的血管发生有关的适应征中的用途，并且涉及生产所述组合物的方法，本发明还涉及6-(6-羟基甲基-嘧啶-4-基氧基)-萘-1-甲酸(3-三氟甲基-苯基)-酰胺的特定形式以及这些形式的制备和用途。本发明还涉及生产6-{6-羟基甲基-嘧啶-4-基氧基)-萘-1-甲酸(3-三氟甲基-苯基)-酰胺的新方法。
摘要（英）：

The present invention relates to pharmaceutical compositions of 6-(6-hydroxymethyl- pyrimidin-4-yloxy)-naphthalene-1-carboxyfic acid (3-trifluoromethyl-phenyl)-amide, to the use of 6-(6-hydroxymethyl-pyrimidin-4-yloxy)-naphthatene-1-carboxylic acid (3-trifluoromethyI- phenyl)-amide and compositions of 6-(6-hydroxymethyl-pyrimidin-4-yloxy)-naphthalene-1- carboxylic acid (3-trifluoromethyi-phenyi)-amide in therapeutic applications, especially indications with a dysregulation/overexpression of VEFG, (neo)-vascularisation and VEGF driven angiogenesis and to methods for manufacturing such compositions, the invention further relates to specific forms of 6-(6-hydroxymethyl-pyrimidin-4-yloxy)-paphthalene-1- carboxyiic acid (3-trifluaromethyl-phenyl)-amide and to the manufacturing and use of such forms.; The present invention also relates to a new process to produce 6-{6-hydroxymethyl- pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide.

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