The invention discloses an aconitine medicinal multi-unit enteric-coated capsule or a multi-unit enteric-coated tablet and a preparation method thereof. A micro-pill consists of hollow pill cores and a coating layer coated outside the hollow pill cores, wherein the coating layer comprises a main medicament layer consisting of a main medicament and auxiliary materials, an isolating layer coated outside the main medicament layer, and an enteric-coated layer coated outside the isolating layer. After a product is treated with a preparation process, the main medicament is not released basically in acids but is released after entering small intestines, so that untoward effects caused by the stimulation of the main medicament on the stomach are avoided. Meanwhile, the phenomenon of excessively high local medicament concentration caused by sudden release of aconitine is avoided simultaneously, and food influence is avoided.